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About

Prelude is a life science technology company looking to make the world safer and healthier by accelerating new product development of life-saving medicine and devices for humans and animals. Our mission is to simplify clinical research through smarter technology and superior service. Clinical trial designs are becoming increasingly complex, making new research more daunting and labor-intensive for clinical research organizations of all sizes. With Prelude’s Clinical Data Management (CDMS) platform, complex research is made easy through the industry’s most user-friendly, flexible eClinical technology platform, enabling easy, adaptable trials and automating 90%+ of clinical data management work.

Description

We are seeking a highly skilled Senior Site Reliability Engineer (SRE) to join our engineering team. In this role, you will play a critical part in ensuring the reliability, scalability, and performance of our AWS-based software products. You’ll collaborate closely with software engineers, DevOps engineers, and architects to drive operational excellence and build resilient, automated infrastructure using modern tools.

This is a high-impact position suited for someone with a strong background in software engineering, a deep understanding of AWS, and a passion for automation, stability, security, observability, and optimization. You will be joining a team that loves working together and supporting each other, and that prioritizes balance in work and life.

This role is hybrid (Tuesday – Thursday in office) and is located in Austin, Texas.

Responsibilities

• Design, implement, manage, and secure scalable infrastructure solutions on AWS using best practices and modern tooling such as AWS CDK.
• Develop and maintain Infrastructure as Code (IaC) using Python or TypeScript.
• Build monitoring, alerting, and observability systems to ensure platform health and operational visibility.
• Partner with software engineering teams to improve service reliability, performance, availability, security, and cost efficiency.
• Lead incident response efforts, postmortems, and root cause analysis to continuously improve system resilience.
• Assist with the design, development, and enforcement of DevOps best practices, including CI/CD, infrastructure automation, and secure deployment strategies.
• Contribute to the strategic direction of our infrastructure roadmap and participate in capacity planning and scaling efforts.
• Assist with software engineering tasks as needed.

Requirements

• 5+ years of experience in Site Reliability, DevOps, or Software Engineering roles.
• Deep, hands-on knowledge of AWS services (e.g., EC2, ECS, Fargate, Lambda, Step Functions, Event Bridge, VPC, S3, IAM) and cloud architecture best practices.
• Significant experience with AWS CDK (Cloud Development Kit) and CloudFormation.
• Proficiency in Python or TypeScript, and a commitment to clean, maintainable, and testable code.
• Strong understanding of Linux systems, networking, and container orchestration.
• Experience securing infrastructure in AWS, and with AWS Security tools such as Security Hub and Guard Duty.
• Experience with AWS and open-source monitoring and observability tools (e.g., CloudWatch, Prometheus, Grafana).
• Familiarity with building and utilizing CI/CD pipelines (e.g., GitHub Actions, CodePipeline) and deployment automation.
• Excellent problem-solving skills, a proactive mindset, and a collaborative, friendly attitude.

Preferred

• AWS certifications (e.g., Solutions Architect, DevOps Engineer) are a plus.
• Experience with the NodeJS ecosystem is a plus
• Experience with MongoDB is a plus
• Experience ensuring compliance in cloud environments, and with SOC 2 Type 2
• Knowledge of distributed systems and high-availability architectures.